On DemandDecoding CAR-T Cell Fitness — Brandon Simone, Gill Lab (UPenn)Webinar: Decoding CAR-T Cell Fitness
Register freeMeet TROVO
High-throughput functional screening, live-cell selection and live-cell recovery — all in a single fluidics-free benchtop system. Watch your cultures. Retrieve the best cells.
Print. Seed. Discover. Retrieve.
What TROVO enables
Not all CRISPR hits, TIL clones or CAR-T constructs are equal. Some edits drive proliferation; others enhance cytotoxicity or persistence. TROVO reveals what bulk screens miss.
TROVO compartmentalizes standard culture plates into thousands of individual hydrogel microwells — no microfluidics, no proprietary plate formats, no workflow changes. Each clone becomes its own experiment, measured under identical conditions.
Learn moreReal-time fluorescence and brightfield imaging tracks cytotoxicity, persistence, proliferation, exhaustion, secretion and migration over hours, days or weeks. Behavioral data that surface markers alone cannot predict.
Learn moreA light-based capture gel recovers functional hits directly from culture — alive, intact and ready for sequencing or expansion. No FACS, no high-pressure sorting, no shear stress.
Learn moreThe workflow
A benchtop, fluidics-free platform that fits inside your existing cell culture workflow — from microwell fabrication to viable recovery of top clones.
3D-printed hydrogel walls compartmentalize a standard culture plate into thousands of discrete microwells in under an hour.
Real-time fluorescence imaging tracks every co-culture over time — identifying functional hits based on what cells actually do.
A light-based capture gel physically recovers cells of interest directly from culture — alive, and ready for sequencing, expansion or further validation.
Microculture applications
Rank constructs by real-time killing kinetics and persistence — not surface markers.
Distinguish responders from non-responders with Z-score-based functional metrics.
Detect rare secretors and recover clones for RT-PCR, sequencing or expansion.
Enrich rare live populations from tumor tissue, biopsy or heterogeneous cultures.
Accelerate clone selection with longitudinal, in-plate functional characterization.
Image-guided, fluidics-free live enrichment for high-integrity scRNA-seq input.
Recognized science
Enrich Biosystems collaborates with academic and industry partners working on CAR-T, TCR-T, TIL, antibody discovery and single-cell workflows — including the Katz Lab at Yale, the Gill Lab at UPenn, City of Hope and Johns Hopkins.
Ready when you are
Speak with the Enrich Biosystems team to discuss how TROVO can support your functional screening, clone selection and live-cell recovery workflow.